How to take the rail journey Hamburg to Frankfurt (Main)

Departing from Hamburg:

Most of these trains commence their journeys at Hamburg-Altona station and they all call at Hamburg-Dammtor before they arrive at Hamburg hbf.

So it can be a good idea to look up the starting point of your journey and then book tickets from the most convenient station; only Hamburg Hbf has connections with the U-Bahn (subway).

Final Destination: Basel or Interlaken or Zurich or Stuttgart

The Sprinter service:

A newly added departure on Mon-Fri at 06:06 will race to Frankfurt (Main) hbf in only 3hr 21min, thanks to it making only one intermediate station call at Hannover.
Though an ICE 1 train is used for this service.

The alternative route:

In most hours there are also now other ICE trains between Hamburg and Frankfurt (Main), but they are around an hour slower than these trains because they don't use the high speed line and take a 'classic' route via Marburg

As a consequence DB doesn't sell tickets for journeys by those slower trains.

But if you will be travelling with a rail pass take care to avoid those trains

Book early and save: Yes
Online bookings usually open: up to 6 months ahead of the travel date - but this period of time is shorter when looking up journeys in August to October.

A choice of tickets

Four types of tickets are available:
Two types of discounted tickets, which will be cheaper the further ahead you book - Sparpreis and Super Sparpreis
Two types of non-discounted ticket - Flexpreis Aktion and Flexpreis

A key difference between these types of tickets is refunds:

• Super Sparpreis tickets are cheapest, but they can't be refunded at all.
• Sparpreis tickets can be refunded for a fee, but the refund will be in the form of travel vouchers to be used for alternative / future journeys.
• Flexpreis tickets can be refunded at no additional charge.
• Flexpreis Aktion tickets can't be refunded either - but their higher cost is due to...

...the other key difference is that both types of Flexpreis tickets live up to their name, as they can be used on any departure on your travel date - in contrast, both types of Sparpreis tickets are only valid on the specific departures selected when booking,

Note that none of the tickets can be exchanged to a different departure.
There's no need for this to be available for both types of Flexpreis tickets, as they aren't train departure specific.
If you book a Sparpreis ticket and want to travel by a different departure you can refund it and then use the travel voucher towards the cost of the new booking.
Super Sparpreis tickets can't be exchanged or refunded.

When travelling to and from the major cities, the Sparpreis, Flexpreis Aktion and Flexpreis tickets also include 'City tickets', which can be used on public transport between locations in the Berlin and Munich city centres and the stations where the trains depart and arrive.

Seat reservations

Seat reservations are optional on ICE trains for journeys within Germany - take note if you will be using a rail pass.
They cost €4.90 when travelling in 2nd Class and €5.90 when travelling in 1st class.
When a journey involves two or more trains on which seat reservations are available, the fees when first booking, cover all trains.
Specific seats can be selected from seating plans - you don't have to accept the seat(s) that you will be automatically offered.

They are included within the cost of booking 1st class Flexpreis tickets and both 1st and 2nd class Flexpreis Plus tickets.
Though despite seats being automatically assigned when booking these three types of ticket - and these tickets being valid on any departure, you will need to pay to re-book the reservations, if you subsequently decide to travel on an alternative train.
So because you won't save by booking these types of tickets in advance, it can be a good idea to wait until you are sure when you will want to travel.

When booking Super Sparpreis, Sparpreis and 2nd class Flexpreis tickets, you have the option of purchasing seat reservations later.
It can be worth re-looking up a journey a week or two ahead of travel, because the DB website will indicate how busy a departure will be.

1st Class tickets

No matter what type of ticket booked, if you choose to travel 1st class, you will have access to the same seating areas on the train, ICE trains do not have Business or Executive lounges.
Though only those who have booked 1st class Flexpreis or Flexpreis Plus tickets can access the DB Lounges at the major stations.

Booking on the DB website

You can find these trains more easily by making a proactive selection of 'Direct Trains Only'.

Or to see all the combinations of trains and journey options, some of which may be cheaper, take off the 'fastest connections' default.

Trains departing at different times can be cheaper than others leaving on the same day, so if you can be flexible with your departure time use the 'best prices' tool - at the top right on the list of journey options.