When taking a train from Lyon to Avignon there is a choice between:
(1) Taking TGV trains, which use the high speed line between the two cities and arrive at the aptly named, Avignon TGV station; which is located 6 km from the city, but it is connected to the edges of the city centre by local trains and buses.
When travelling between most cities by train there is only one logical option, though on other journeys there is a choice between different trains or alternative routes. If different options are available you can use the info to decide which is best for you.
1hr 10min - 1hr 15min approx
Monday - Thursday = 12 x trains per day
Friday = 14 x trains
Saturday = 13 x trains
Sunday = 12 x trains
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This is one of more than 100 train travel guides available on ShowMeTheJourney, which will make it easier to take the train journeys you want or need to make. As always, all images were captured on trips taken by ShowMeTheJourney.