The overnight services from Zurich to Prague/Praha are the only direct trains from Switzerland to Czechia.
Travelling by day on trains from Zurich to Prague/Praha involves making connections in Linz OR Munchen/Munich, but on both routes the connections on to Czechia involve fairly lengthy journeys on regional trains, which lack the ambience and facilities typically found on express trains.
But what's new is that from December 11th and into 2023 there will be a choice of two overnight train services when travelling from Switzerland's largest city to the capital of Czechia.
When travelling between most cities by train there is only one logical option, though on other journeys there is a choice between different trains or alternative routes. If different options are available you can use the info to decide which is best for you.
13hr 39min
Nightly
1 x train per night
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This is one of more than 100 train travel guides available on ShowMeTheJourney, which will make it easier to take the train journeys you want or need to make. As always, all images were captured on trips taken by ShowMeTheJourney.