The overnightservices from Prague/Praha to Zurich are the only direct trains from Czechia to Switzerland.
Travelling by day on trains from Prague/Praha to Zurich involves making connections in Linz OR Munchen/Munich, but on both routes the connections on to Czechia involve fairly lengthy journeys on the type of trains typically used for regional services, so they lack the ambience and facilities typically found on express trains.
But what's new is that from December 11th and into 2023 there will be a choice of two overnight train services when travelling from the capital of Czechia to Switzerland's largest city.
When travelling between most cities by train there is only one logical option, though on other journeys there is a choice between different trains or alternative routes. If different options are available you can use the info to decide which is best for you.
14hr 39min
Nightly
1 x train per night
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This is one of more than 100 train travel guides available on ShowMeTheJourney, which will make it easier to take the train journeys you want or need to make. As always, all images were captured on trips taken by ShowMeTheJourney.