Yes the journey from Basel to Wengen requires taking three different trains, but the two connections are as simple as can be, and the second half of the end-to-end trip is astonishingly beautiful.
If you will be heading to Wengen on a combination of plane + train, the fact you will need to make the transfer by bus from Basel/Mulhouse airport to Basel SBB station, is offset in terms of convenience by the fact that Basel is the only key entry point into Switzerland, which has direct trains to Interlaken.
The next stage of the ride to Wengen involves taking a train on from Interlaken Ost station.
When travelling between most cities by train there is only one logical option, though on other journeys there is a choice between different trains or alternative routes. If different options are available you can use the info to decide which is best for you.
2hr 52min
Daily
1 x connection per hour
Change trains in: Interlaken and Lauterbrunnen
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This is one of more than 100 train travel guides available on ShowMeTheJourney, which will make it easier to take the train journeys you want or need to make. As always, all images were captured on trips taken by ShowMeTheJourney.